Axitinib
| Overview | |
| Catalog # | bs-80414C |
| Product Name | Axitinib |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:386.47 Formula:C22H18N4OS Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml). Chemical Name:N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide |
| Description | Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3 Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.4 |
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