Myriocin (ISP-1)
| Overview | |
| Catalog # | bs-80401C |
| Product Name | Myriocin (ISP-1) |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:401.54 Formula:C21H39NO6 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml). Chemical Name:(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid |
| Description | Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3 |
Powered by Bioz