Cerulenin

Overview
Catalog #	bs-80387C
Product Name	Cerulenin
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:223.27 Formula:C12H17NO3 Purity:>98% Solubility:Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml). Chemical Name:2,3-Epoxy-4-oxo-7,10-dodecadienamide
Description	Fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM1. Produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream of, both leptin and melanocortin receptors2. Reduces nutrient-induced insulin release from normal rat islets3. Induces apoptosis in human melanoma A-375 cells4.