DRB

Overview
Catalog #	bs-80380C
Product Name	DRB
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:319.14 Formula:C12H12Cl2N2O4 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) Chemical Name:5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
Description	A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5