FPS-ZM1
| Overview | |
| Catalog # | bs-80364C |
| Product Name | FPS-ZM1 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:327.1 Formula:C20H22ClNO Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml) Chemical Name:4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide |
| Description | A high-affinity RAGE (Receptor for Advanced Glycation End products) antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo1,2. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage3. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling4. Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia5. BBB permeable. |
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