Fasnall HCl

Overview
Catalog #	bs-80358C
Product Name	Fasnall HCl
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:374.93 Formula:C19H22N4S HCl Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml) Chemical Name:5,6-Dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]thieno[2,3-d]pyrimidin-4-amine benzenesulfonate hydrochloride
Description	A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model1. Reduces HIV-1 virion production by 90% (EC50=213 nM).2