GAC Inhibitor 968
Overview | |
Catalog # | bs-80326C |
Product Name | GAC Inhibitor 968 |
Specifications | |
Storage Buffer | powder |
Storage Condition | RT |
Target | |
Product Information | Molecular Weight:475.4 Formula:C27H27BrN2O Purity:>98% Solubility:Soluble in DMSO (up to (11 mg/ml); or ethanol (up to 1 mg/ml, warm) Chemical Name:5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one |
Description | Allosteric inhibitor of glutaminase C (GAC)1. Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells2. Inhibits liver-type glutaminase GLS2 and suppresses breast tumor growth in vivo3,4. Reverses acquired erlotinib resistance in non-small cell lung cancer5. |