STF-083010
Overview | |
Catalog # | bs-80306C |
Product Name | STF-083010 |
Specifications | |
Storage Buffer | powder |
Storage Condition | RT |
Target | |
Product Information | Molecular Weight:317.39 Formula:C15H11NO3S2 Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) Chemical Name:N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide |
Description | A novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in model human MM xenografts1. Induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer4. Active in vivo. |