ML-239

Overview
Catalog #	bs-80243C
Product Name	ML-239
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:346.60 Formula:C13 H10 Cl3 N3 O2 Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml), or in Ethanol (up to 25 mg/ml) Chemical Name:(2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
Description	A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3