Importazole

Overview
Catalog #	bs-80240C
Product Name	Importazole
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:318.43 Formula:C20H22N4 Purity:>98% Solubility:Soluble in DMSO (up to 10 mg/ml). Chemical Name:N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
Description	Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export1. When added to cells during mitosis it impairs the release of an importin- cargo probe and causes defects in spindle assembly. Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-/RanGTP pathway2-4. Cell permeable