KL-001

Overview
Catalog #	bs-80239C
Product Name	KL-001
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:398.46 Formula:C21H22N2O4S Purity:>98% Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming). Chemical Name:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Description	A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.