LM22A-4

Overview
Catalog #	bs-80234C
Product Name	LM22A-4
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:339.35 Formula:C15H21N3O6 Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml). Chemical Name:N,N’N’ Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Description	Small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats1. Improves respiratory function in a mouse models of Rett syndrome2.