GSK-J4

Overview
Catalog #	bs-80229C
Product Name	GSK-J4
Specifications
Storage Buffer	wax
Storage Condition	-20°C
Target
Product Information	Molecular Weight:417.48 Formula:C24H27N5O2 Purity:>98% Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml). Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Description	Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.