Indirubin

Overview
Catalog #	bs-80224C
Product Name	Indirubin
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:262.3 Formula:C16H10N2O2 Purity:>98% Solubility:Soluble in DMSO (up to 10 mg/ml). Chemical Name:3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
Description	Natural product that acts as an inducer of human AhR-dependent gene expression with 10-fold greater potency over the endogenous agonist TCDD1. Indirubin also inhibits CDKs (IC50 = 50–100 nM) and GSK-3β (IC50 = 5-50 nM)2. Ameliorates the effects of a high-fat diet on mice3. Breaks the inflammatory cycle in in vitro and in vivo models of psoriasis4. Inhibits angiogenesis and causes autophagy and apoptosis in cancer cells5,6.