Spautin-1

Overview
Catalog #	bs-80215C
Product Name	Spautin-1
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:271.27 Formula:C15H11F2N3 Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming). Chemical Name:6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
Description	A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable.