SMI-4a
| Overview | |
| Catalog # | bs-80208C |
| Product Name | SMI-4a |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:273.23 Formula:C11H6F3NO2S Purity:>98% Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming). Chemical Name:5-(3-Trifluoromethylbenzylidene)thiazolidine |
| Description | A selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases1. Induces cell cycle arrest in leukemia and prostate cancer cells2. Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive3. A useful tool for exploring the involvement of Pim in cellular signaling4. Cell permeable. |
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