Wiskostatin

Overview
Catalog #	bs-80204C
Product Name	Wiskostatin
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:426.15 Formula:C17H18Br2N2O Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml). Chemical Name:1-(3,6-Dibromocarbazol-9-yl)-3-dimethylaminopropan-2-ol
Description	A selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity1. Binds to the regulatory domain of N-WASP and inhibits activation of Arp2/3 complex by forcing N-WASP into an inactive conformation2. Inhibits PIP2-induced actin polymerization (EC50=4 μM). Perturbs agrin-elicited acetylcholine receptor clustering3. Inhibits the formation of dendritic spines and synapses in hippocampal neurons4.