b-AP15 (NSC-687852)
| Overview | |
| Catalog # | bs-80196C |
| Product Name | b-AP15 (NSC-687852) |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:419.40 Formula:C22H17N3O6 Purity:>98% Solubility:Soluble in DMSO (up to 35 mg/ml). Chemical Name:3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one |
| Description | Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. |
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