C16

Overview
Catalog #	bs-80189C
Product Name	C16
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:268.30 Formula:C13H8N4OS Purity:>98% Solubility:Soluble in DMSO (up to 15 mg/ml, with warming). Chemical Name:6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Description	Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM)1. Inhibits ER stress-induced neuronal damage2. Reduces brain PKR activation in vivo3. Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model4. Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures5. Cell permeable.