LDN-57444
Overview | |
Catalog # | bs-80175C |
Product Name | LDN-57444 |
Specifications | |
Storage Buffer | powder |
Storage Condition | -20°C |
Target | |
Product Information | Molecular Weight:397.65 Formula:C17H11Cl3N2O3 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml). Chemical Name:5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) |
Description | Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable. |