TG003

Overview
Catalog #	bs-80167C
Product Name	TG003
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:249.33 Formula:C13H15NO2S Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 15 mg/ml). Chemical Name:(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
Description	Potent, ATP-competitive inhibitor of Clk-family kinases (IC50s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3)1. Also inhibits DYRK1A/B (IC50s = 24 and 34 nM respectively)2. Suppresses serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles and Clk1/Sty-dependent alternative splicing in mammalian cells1. Affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. Promotes skipping of exon 31 in the endogenous dystrophin gene3. Increases levels of Clk1/4 mature mRNAs by promoting splicing of the intron-retaining RNAs4.