Cytarabine

Overview
Catalog #	bs-80157C
Product Name	Cytarabine
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:243.2 Formula:C9H13N3O5 Purity:>98% Solubility:Soluble in DMSO (up to 12 mg/ml), or in Water (up to 24 mg/ml). Chemical Name:4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Description	A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells1,2. Cellular enzymes convert it to its phosphorylated form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it3,4. For the same reasons, it is also employed as an antiviral5. It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML)6,7.