Xestospongin C

Overview
Catalog #	bs-80137C
Product Name	Xestospongin C
Specifications
Storage Buffer	Lyophilized
Storage Condition	-20°C
Target
Product Information	Molecular Weight:446.7 Formula:C28H50N2O2 Purity:>97% Solubility:Soluble in DMSO (up to 10 mg/ml) Chemical Name:Natural product isolated from the marine sponge Xestospongia sp.
Description	A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM1. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling3. Cell permeable.