XAV-939

Overview
Catalog #	bs-80121C
Product Name	XAV-939
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:312.31 Formula:C14H11F3N2OS Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml). Chemical Name:2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
Description	Tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively). Antagonizes Wnt signaling downstream of receptor activation via stabilization of axin, a negative regulator of β-catenin1. Robustly induces cardiomyogenesis of stem cells2. Reduces experimental fibrosis in a mouse model of bleomycin-induced dermal fibrosis3. Promotes apoptosis in a neuroblastoma cell line via telomere shortening4. An important tool for probing the activation of the Wnt/β-catenin pathway in cells5. Cell permeable.