Zileuton

Overview
Catalog #	bs-80064C
Product Name	Zileuton
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:236.29 Formula:C11H12N2O2S Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml). Chemical Name:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Description	Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO).