Dorsomorphin

Overview
Catalog #	bs-80017C
Product Name	Dorsomorphin
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:399.49 Formula:C24H25N5O Purity:>98% Solubility:Soluble in DMSO (up to 3 mg/ml). Chemical Name:6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
Description	Potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).2 Dorsomorphin has been shown to promote cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro.3 Induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.4