GSK-3787

Overview
Catalog #	bs-80001C
Product Name	GSK-3787
Specifications
Storage Buffer	Powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:392.8 Formula:C15H12ClF3N2O3S Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml). Chemical Name:4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Description	Selective and irreversible antagonist of peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) (plC50 = 6.6), but not PPARα or ɣ1,2. It covalently binds to Cys 249 in the PPARβ/δ binding site1. When applied topically, GSK-3787 showed efficacy against an inflammatory skin disease resembling psoriasis in mice3. Suppresses colorectal cancer tumorigenesis in Apc(δ580) mice4.