| Overview |
| bs-7852R-PE-Cy3 |
| ZWINT Polyclonal Antibody, PE-Cy3 Conjugated |
| WB |
| Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Rabbit |
| Specifications |
| PE-Cy3 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human ZWINT |
| 85-170/277 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 11130 |
| Nucleus |
| HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZW10 interactor; ZWINT 1; ZWINT1; ZWINT-1; ZWINT_HUMAN. |
| ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis. |
| Application Dilution |
| WB |
1:300-5000 |
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