Aloin

Overview
Catalog #	bs-75881c-50mg
Product Name	Aloin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 1415-73-2 Molecular formula: C21H22O9 Molecular weight: 418.39 Purity: >98% (HPLC) Appearance: Yellow Powder. Solubility: Soluble in DMSO or methanol (both 50mg/ml). InChiKey: AFHJQYHRLPMKHU-OSYMLPPYSA-N SMILES: OC1=C2C([C@@]([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)([H])C(C=C(CO)C=C4O)=C4C2=O)=CC=C1
Description	Aloin is a naturally occurring substance found in various Aloe plant species. Aloin was originally used as a laxative in the treatment of constipation. Aloin is a chemopreventive and antineoplastic agent. It is a cytotoxic against cancer cells. As a anticancer agent it inhibits Topoisomerase II alpha, induces apoptosis, targets High Mobility Group Box 1 (HMGB1) and inhibits angiogenesis. It has been shown to be a potent skin depigmenting agent, enhancing melanogenesis. It has been described as a tyroniase inhibitor. It regulates transglutaminase activity. In addition Aloin is an anti-inflammatory agent, inhibiting the NF-kappaB pathway, antitrypanosomal, iron chelating and microbiota modulating compound.