Amikacin disulfate salt

Overview
Catalog #	bs-75858c-1g
Product Name	Amikacin disulfate salt
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 39831-55-5 Molecular formula: C22H43N5O13 . 2H2SO4 Molecular weight: 781.76 Purity: >97% (NMR) Appearance: White to off-white powder. Solubility: Soluble in water (50mg/ml). InChiKey: FXKSEJFHKVNEFI-GCZBSULCSA-N SMILES: OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]([C@@H]([C@H]1N)O[C@H]([C@@H]([C@H]2O)O)O[C@H](CN)[C@H]2O)[C@H]([C@@H](C1)N([H])C([C@H](CCN)O)=O)O[C@H]([C@@H]([C@H]3N)O)O[C@H](CO)[C@H]3O
Description	Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection.