Adenine 9-beta-D-arabinofuranoside

Overview
Catalog #	bs-75857c-5g
Product Name	Adenine 9-beta-D-arabinofuranoside
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 5536-17-4 Molecular formula: C10H13N5O4 Molecular weight: 267.24 Purity: >99% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in DMSO (20mg/ml) or DMF (5mg/ml). Slightly soluble in water (1mg/ml). InChiKey: OIRDTQYFTABQOQ-UHTZMRCNSA-N SMILES: NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
Description	Adenine 9-beta-D-arabinofuranoside is an analog of the nucleoside adenosine that has antiviral properties. It acts as a prodrug that, once phosphorylated by cellular enzymes, acts as both substrate and inhibitor of DNA polymerase. It has been shown to be effective against H. simplex, V. zoster and Epstein-Barr viruses. It is a potent inhibitor of AMP-activated protein kinase (AMPK) in liver, muscle and cardiac cells H9c2. It is also a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes and showed anti-neoplastic activities. It has been shown to have inhibitory activity against SARS-CoV-2-ACE2 binding.