Seriniquinone

Overview
Catalog #	bs-75796c-1mg
Product Name	Seriniquinone
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C.Stock solutions are stable for 3 months when stored at -20°C.
Target
Product Information	CAS Number: 22200-69-7 Molecular formula: C20H8O4S Molecular weight: 344.3 Purity: >99% (HPLC) Appearance: Yellow to orange solid. Solubility: Soluble in DMSO (10mg/ml) or DMF (15mg/ml). Insoluble in water. InChiKey: PWUWIMAXHCTYJA-UHFFFAOYSA-N SMILES: O=C1C(C2=C3C(C4=C(C2=O)C=CC=C4)=O)=C(S3)C(C5=CC=CC=C51)=O
Description	Seriniquinone is a potent cytotoxic and melanoma-selective anticancer agent. Upon cellular treatment and based on the compounds fluorescent nature it was found localized in the endoplasmic reticulum. Seriniquinone inhibits cell proliferation marked by autophagocytosis and induces cell death due to caspase-9 dependent apoptosis. Mode of action studies suggest that it specifically targets a skin protective antimicrobial peptide dermcidin (DCD), whose role as a cancer-protective protein has been recently recognized.