Phomoxanthone A

Overview
Catalog #	bs-75781c-5mg
Product Name	Phomoxanthone A
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at +4°C.
Target
Product Information	CAS Number: 359844-69-2 Molecular formula: C38H38O16 Molecular weight: 750.7 Purity: >97% (1H-NMR, HPLC) Appearance: Pale yellow solid. Solubility: Soluble in DMSO, methanol or acetone. Insoluble in water. InChiKey: OHHXJWHRQGZQJM-CMDKCIDSSA-N SMILES: C[C@H]1CC(O)=C2C(=O)C3=C(O[C@@]2(COC(C)=O)[C@H]1OC(C)=O)C(=CC=C3O)C1=C2O[C@@]3(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C3C(=O)C2=C(O)C=C1
Description	Mycotoxin Antibacterial against Gram-positive bacteria. Shows antimalarial and antitubercular activity. Anticancer compound. Cytotoxic against several cancer cell lines (pro-apoptotic activity). Active against plant pathogene fungi (e.g. P. oryza, Phyt. infestans). Activator of murine T lymphocytes, NK cells and macrophages. Mitochondrial toxin with a mode of action distinct from known electron transport chain (ETC) inhibitors, OXPHOS uncouplers and ionophores. Shows rapid inhibition of both ETC and DeltaPsim, the release of mitochondrial Ca2+ and fission of the inner but not the outer mitochondrial membrane independent from the mitochondrial fission and fusion regulators DRP1 and OPA1.