Famotidine

Overview
Catalog #	bs-75611c-1g
Product Name	Famotidine
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 76824-35-6 Molecular formula: C8H15N7O2S3 Molecular weight: 337.5 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO (30mg/ml) or DMF (30mg/ml). InChiKey: XUFQPHANEAPEMJ-UHFFFAOYSA-N SMILES: N/C(N)=N/C1=NC(CSCC/C(N)=N/S(=O)(N)=O)=CS1
Description	Famotidine is a histamine H2 receptor antagonist. It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex). Famotidine blocks the action of histamine in the parietal cells, ultimately blocking acid secretion in the stomach. It inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6µM) and suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400µg/kg, respectively). Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD) and heartburn and it decreases the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs). Potential inhibitor of the viral enzyme papain-like protease (PLpro), important for SARS-CoV-2 replication and being tested in COVID-19 clinical trials.