Darunavir . ethanolate

Overview
Catalog #	bs-75605c-10mg
Product Name	Darunavir . ethanolate
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 635728-49-3 Molecular formula: C27H37N3O7S . C2H5OH Molecular weight: 547.7 . 46.0 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO (30mg/ml). Very slightly soluble in water (~0.15mg/ml). InChiKey: QWSHKNICRJHQCY-VBTXLZOXSA-N SMILES: NC1=CC=C(S(=O)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CO[C@]4([H])[C@@]3([H])CCO4)=O)CC(C)C)=O)C=C1.CCO
Description	Darunavir ethanolate is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. The ethanolate formulation has some stability advantages compared to the free base Darunavir (Prod. No. bs-75605C). Darunavir ethanolate is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain like viral protease (PLVP) of SARS-CoV-2, responsible for COVID-19.