Sunitinib . malate
| Overview | |
| Catalog # | bs-75590c-1mg |
| Product Name | Sunitinib . malate |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 341031-54-7 Molecular formula: C22H27FN4O2 . C4H6O5 Molecular weight: 398.5 . 134.1 Purity: >98% Appearance: Solid. Solubility: Soluble in DMSO (10mg/ml) or ethanol. InChiKey: LBWFXVZLPYTWQI-IPOVEDGCSA-N SMILES: O[C@@H](CC(O)=O)C([O-])=O.[H][N+](CC)(CC)CCNC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C |
| Description | Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models. |
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