alpha-Cyano-4-hydroxycinnamic acid

Overview
Catalog #	bs-75573c-1g
Product Name	alpha-Cyano-4-hydroxycinnamic acid
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 28166-41-8 Molecular formula: C10H7NO3 Molecular weight: 189.2 Purity: >98% Appearance: White to yellow solid. Solubility: Soluble in DMSO (10mg/ml) or methanol (5mg/ml). InChiKey: AFVLVVWMAFSXCK-VMPITWQZSA-N SMILES: OC1=CC=C(/C=C(C#N)/C(O)=O)C=C1
Description	Specific monocarboxylate transporter (MCT) inhibitor. Inhibits mitochondrial lactate and pyruvate transport. Decreases glycolysis. Useful agent for immunometabolism research. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration and invasion. Blocks lactate efflux from glioma cells and sensitizes cells to irradiation. Highly malignant tumors rely heavily on aerobic glycolysis (metabolism of glucose to lactic acid even under presence of oxygen; Warburg Effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from apoptosis. Inhibiting lactic acid efflux is a very effective therapeutic strategy against highly glycolytic malignant tumors. Common organic matrix-assisted laser desorption/ionization (MALDI) matrix.