3-Guanidinopropionic acid

Overview
Catalog #	bs-75566c-500mg
Product Name	3-Guanidinopropionic acid
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 353-09-3 Molecular formula: C4H9N3O2 Molecular weight: 131.1 Purity: >98% Appearance: White powder. Solubility: Soluble in water (50mg/ml) or other aqueous buffers (e.g. PBS). InChiKey: KMXXSJLYVJEBHI-UHFFFAOYSA-N SMILES: NC(NCCC(O)=O)=N
Description	Competitive creatine uptake inhibitor. Creatine analog that alters skeletal muscle energy expenditure. Thermogenesis inhibitor. Inhibitor of energy expenditure through reduction of ATP. AMPK stimulator and PGC-1alpha activator. Reduces cellular ATP, creatine and phosphocreatine levels, consequently stimulating AMP-activated protein kinase (AMPK) and activating PPARgamma coactivator 1alpha (PGC-1alpha). Evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake and increased fatigue tolerance. Ameliorates hyperglycemia in animal models of non-insulin-dependent diabetes (NIDDM). Improved insulin sensitivity and promoted weight loss selectively from adipose tissue. Studied for potential use during protein refolding as an anti-aggregatory molecule similar to L-arginine.