PTACH [NCH 51]
| Overview | |
| Catalog # | bs-75556c-5mg |
| Product Name | PTACH [NCH 51] |
| Specifications | |
| Storage Buffer | Crystals |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 848354-66-5 Molecular formula: C20H26N2O2S2 Molecular weight: 390.56 Purity: >97% (HPLC) Appearance: White crystals. Solubility: Soluble in DMSO (25mg/ml) or ethanol (10mg/ml). Insoluble in water. InChiKey: MDYDGUOQFUQOGE-UHFFFAOYSA-N SMILES: CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C1=CC=CC=C1 |
| Description | Potent non-hydroxamate HDAC inhibitor (HDACi) (IC50: 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively). Cell permeable prodrug that is intracellularly converted to the potent HDAC inhibitor NCH 31. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro (EC50=1.1 - 9.1µM). Reactivates latent HIV-1 gene expression. Active against selected neurodevelopmental disorders. |
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