TBB

Overview
Catalog #	bs-75552c-5mg
Product Name	TBB
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 17374-26-4 Molecular formula: C6HBr4N3 Molecular weight: 434.7 Purity: >98% (HPLC) Appearance: Solid. Solubility: Soluble in DMSO (20mg/ml). InChiKey: OMZYUVOATZSGJY-UHFFFAOYSA-N SMILES: BrC1=C(Br)C(Br)=C(Br)C2=C1N=NN2
Description	ATP/GTP-competitive cell permeable casein kinase II (CK2) inhibitor (IC50=0.9µM for rat liver. Less potently inhibits CCK2/cyclin A, GSK3beta and phosphorylase kinase (IC50=15.6, 11.2 and 8.7µM, respectively). Binds to the Val66 residue of CK2 and inhibits the binding of ATP/GTP. Moderate DYRK1A inhibitor (IC50=4.4µM). Induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.