PF-2545920

Overview
Catalog #	bs-75534c-1mg
Product Name	PF-2545920
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 898562-94-2 Molecular formula: C25H20N4O Molecular weight: 392.5 Purity: >98% (HPLC) Appearance: Solid. Solubility: Soluble in DMSO or ethanol. Insoluble in water. InChiKey: AZEXWHKOMMASPA-UHFFFAOYSA-N SMILES: CN(C=C1C2=CC=NC=C2)N=C1C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4
Description	Potent and selective phosphodiesterase 10A (PDE10A) inhibitor (IC50=1.26nM) in vitro and in vivo. PDE10A is a cGMP and cAMP degrading PDE isozyme with neurological importance and was shown to be implicated in the regulation of energy homeostasis. Inhibition of PDE10A leads to interference of the breakdown of the secondary messenger cAMP and cGMP. Anti-psychotic agent. Useful for the treatment of schizophrenia. Anticancer agent. Inhibits colon tumor cell growth for which high levels of PDE10A have been reported. Antiobesity and antidiabetic agent. Induces browning in white adipose tissue (WAT).