Ibrutinib

Overview
Catalog #	bs-75520c-5mg
Product Name	Ibrutinib
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 936563-96-1 Molecular formula: C25H24N6O2 Molecular weight: 440.5 Purity: >98% (HPLC) Appearance: White solid. Solubility: Soluble in DMSO. Slightly soluble in ethanol (1mg/ml). Insoluble in water. InChiKey: XYFPWWZEPKGCCK-GOSISDBHSA-N SMILES: NC1=C2C(=NC=N1)N(N=C2C1=CC=C(OC2=CC=CC=C2)C=C1)C1CCCN(C1)C(=O)C=C
Description	Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).