Cisplatin

Overview
Catalog #	bs-75499c-50mg
Product Name	Cisplatin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 15663-27-1 Molecular formula: Cl2H6N2Pt Molecular weight: 300 Purity: >98% Appearance: Yellow solid. Solubility: Soluble in DMF or DMSO. Sparingly soluble in water. Insoluble in ethanol. InChiKey: LXZZYRPGZAFOLE-UHFFFAOYSA-L SMILES: N[Pt](N)(Cl)Cl
Description	Potent platinum-based antineoplastic agent [1, 10]. Anticancer compound [1]. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death [2, 12, 13, 15]. Nephrotoxic when used in vivo [3]. Potent chemoimmunotherapeutic. Stimulates the immune responses by activating macrophages and other cells of the immune system [4, 6]. Apoptosis inducer via p53-dependent and -independent mechanisms [5, 7, 8]. Induces apoptosis through caspase-3 activation and XIAP expression inhibition [9, 14]. Targets other proteins and enzymes [10]. Non-competitive NHE-1 inhibitor, an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter [16].