Loxoribine

Overview
Catalog #	bs-75493c-5mg
Product Name	Loxoribine
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for 3 months when stored at -20°C.
Target
Product Information	CAS Number: 121288-39-9 Molecular formula: C13H17N5O6 Molecular weight: 339.3 Purity: >97% Appearance: White to off-white powder. Solubility: Soluble in DMSO (30mg/ml) or water (10mg/ml). InChiKey: VDCRFBBZFHHYGT-HKPXRNTQDL SMILES: NC1=NC2=C(N(CC=C)C(=O)N2[C@@H]2O[C@H](CO)C(O)[C@@H]2O)C(=O)N1
Description	Guanosine analog derivatized at position N7 and C8 [1]. Very potent immunostimulatory compound that increases cytokine production [2-5]. Antitumor and antiviral activity compound [5, 6, 7, 12]. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) [7-10]. Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8 [11]. Induces autophagy and autophagy-induced cell death in Caco-2 cells [12]. Shows adjuvant activity to increase the effectiveness of vaccines [4].