R-848

Overview
Catalog #	bs-75491c-5mg
Product Name	R-848
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for 3 months when stored at -20°C.
Target
Product Information	CAS Number: 144875-48-9 Molecular formula: C17H22N4O2 Molecular weight: 314.4 Purity: >98% Appearance: White to off-white powder. Solubility: Soluble in DMSO, dichloromethane or methanol. Slightly soluble in acetonitrile or ethyl acetate. InChiKey: BXNMTOQRYBFHNZ-DZQCGVKKCS SMILES: CCOCC1=NC2=C(N1CC(C)(C)O)C1=C(C=CC=C1)N=C2N
Description	Immune response modifier. Potent antitumor and antiviral compound [1, 3, 10, 11, 13, -16]. Stimulates antibody secretion and cytokine production [2]. Used as adjuvant to increase the effectiveness of vaccines [2, 7, 9, 10]. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human [4-6]. Activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway and leads to the induction of NF-kappaB [4]. NLRP3/NALP3 inflammasome activator, independent of TLRs and RIG-I [8]. Upregulator of the opioid growth factor receptor [12]. Used in the treatment of skin lesions such as herpes simplex virus [16].