IHR-NAc

Overview
Catalog #	bs-75452c-1mg
Product Name	IHR-NAc
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C.
Target
Product Information	CAS Number: n.d. Molecular formula: C22H16Cl3N3O3 Molecular weight: 476.7 Purity: >98% (NMR) Appearance: White to grey solid. Solubility: Soluble in DMSO. InChiKey: KEKPTYABAFCFOT-UHFFFAOYSA-N SMILES: CC(=O)NC1=CC=C(Cl)C(=C1)C(=O)NC1=CC=C(NC(=O)C2=C(Cl)C=CC(Cl)=C2)C=C1
Description	Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.