RO-3306

Overview
Catalog #	bs-75440c-1mg
Product Name	RO-3306
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 872573-93-8 Molecular formula: C18H13N3OS2 Molecular weight: 351.5 Purity: >95% (NMR) Appearance: Brown solid. Solubility: Soluble in DMSO. InChiKey: XOLMRFUGOINFDQ-YBEGLDIGSA-N SMILES: O=C1N=C(NCC2=CC=CS2)S\C1=C/C1=CC2=C(C=C1)N=CC=C2
Description	Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A) [1-3, 5]. Potential anti-cancer compound [1, 8]. Cell cycle arrest inducer at G1, S and G2/M [2, 7] . Apoptosis inducer in embryonic stem cells [4]. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines [6]. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387 [8, 9]. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards [9].