SMI-4a

Overview
Catalog #	bs-75430c-5mg
Product Name	SMI-4a
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 327033-36-3 Molecular formula: C11H6F3NO2S Molecular weight: 273.2 Purity: >95% (NMR) Appearance: White to off-white solid. Solubility: Soluble in DMSO (at least 5 mg/ml). InChiKey: NGJLOFCOEOHFKQ-YVMONPNESA-N SMILES: FC(F)(F)C1=CC(\C=C2/SC(=O)NC2=O)=CC=C1
Description	Selective inhibitor of Pim-1 and Pim-2 protein kinases [1-5]. Inducer of G1 phase cell cycle arrest [1-5]. Inducer of p27Kip1 [1-5]. Inducer of apoptosis through the mitochondrial pathway [1-5]. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway [1-5]. Downregulates c-myc [1-5]. Inhibitor of PRAS40 phosphorylation and mTOR activity [1-5]. Potential anti-cancer compound [2,4,5]. Blocks prostate cancer growth [2,4,5]. Suppressor of cytokines production in lipopolysaccharide (LPS)-induced acute lung injury (ALI)