TOFA

Overview
Catalog #	bs-75425c-5mg
Product Name	TOFA
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 54857-86-2 Molecular formula: C19H32O4 Molecular weight: 324.5 Purity: >98% Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml), DMF (5mg/ml) or ethanol (5mg/ml). InChiKey: CZRCFAOMWRAFIC-UHFFFAOYSA-N SMILES: CCCCCCCCCCCCCCOC1=CC=C(C(O)=O)O1
Description	Fatty acid synthase (FASN) inhibitor. Cell permeable, potent, reversible and competitive inhibitor of acetyl-CoA carboxylase (ACC) consequently blocking the synthesis of malonyl-CoA. Useful agent for immunometabolism research. Anticancer agent. Induces apoptosis in a variety of tumor cell lines. Relatively non-cytotoxic to various cancer cell lines. TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (AG-CR1-2904) on food intake in fasted mice and on apoptosis in tumor cells. Hypolipidemic agent. Stimulates citrate accumulation in the cell, which leads to a suppression of glycolysis by citrate-induced inhibition of phosphofructokinase.