Necrostatin-1

Overview
Catalog #	bs-75421c-5mg
Product Name	Necrostatin-1
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for 3 months when stored at -20°C.
Target
Product Information	CAS Number: 4311-88-0 Molecular formula: C13H13N3OS Molecular weight: 259.3 Purity: >98% (HPLC) Appearance: Off-white to yellow solid. Solubility: Soluble in DMSO, ethanol or dimethylformamide. InChiKey: TXUWMXQFNYDOEZ-UHFFFAOYSA-N SMILES: CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O
Description	Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor [1, 4, 9, 10]. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor [2, 5]. Showed neuroprotection in a murine model of ischemic brain injury in vivo [2, 3]. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor [6, 7]. Used in inflammatory and degenerative disease models to target RIPK1 [7, 9, 10]. Suppresses autophagy and apoptosis in murine brain injury models [8, 9]. Cardioprotective and neuroprotective [11-14].